Receptor Grade IGF-1 LR3 (1mg)

€150.00

Size: 1mg
Contents: Receptor Grade IGF-1 LR3 (1mg)
Form: Lyophilized powder
Purity: >99%
SKU: P-IGF1LR3-1

Categories: Peptides for Sale, Research Peptides for Sale

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Receptor Grade IGF-1 LR3 (1mg) – Research Peptide

Receptor Grade IGF-1 LR3 (1mg) is a synthetic analogue of insulin-like growth factor-1 (IGF-1) supplied as a lyophilised research peptide. Also known as Long R3 IGF-1, Long-(Arg3) IGF-1 and IGF-1 Long Chain R3, this modified peptide has an extended N-terminal structure and an arginine substitution at residue 3.

These structural characteristics have made IGF-1 LR3 a subject of laboratory research investigating growth-factor signalling, IGF receptor biology, cellular responses and interactions with IGF-binding proteins.

This 1mg Receptor Grade IGF-1 LR3 presentation is listed with a purity of >99% and is supplied in lyophilised powder form. The product is intended exclusively for research, laboratory and analytical applications and is not intended for human or animal consumption.

What Is Receptor Grade IGF-1 LR3?

IGF-1 LR3 is a modified form of insulin-like growth factor-1, a naturally occurring protein involved in numerous biological signalling processes. Native human IGF-1 consists of 70 amino acids, while the LR3 analogue contains 83 amino acids due to an additional 13-amino-acid sequence at the N-terminus.

IGF-1 LR3 also contains an arginine residue at position 3, giving the peptide its “Long R3” designation. Researchers have investigated these structural modifications because they alter the molecule’s interaction with IGF-binding proteins and its behaviour in experimental systems.

The term Receptor Grade refers to the product’s research-grade purity classification. Core Peptides lists this material at greater than 99% purity and distinguishes it from its Media Grade IGF-1 LR3 material.

Receptor Grade IGF-1 LR3 (1mg) Product Specifications

Specification	Details
Product Name	Receptor Grade IGF-1 LR3
Quantity	1mg
Form	Lyophilised powder
Purity	>99%
SKU	P-IGF1LR3-1
Category	Research Peptide
Molecular Formula	C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight	9,117.5 g/mol
Alternative Names	Long-(Arg3) IGF-1, Long R3 IGF-1, IGF-1 Long Chain R3
Intended Application	Research, laboratory and analytical use

The product specifications above reflect the information currently published on the Core Peptides product page.

IGF-1 LR3 Structure and Molecular Characteristics

The molecular structure of IGF-1 LR3 distinguishes it from naturally occurring IGF-1. While native IGF-1 contains 70 amino acids, IGF-1 LR3 contains 83 amino acids because of its 13-amino-acid N-terminal extension.

A second modification occurs at residue 3, where the peptide contains arginine. Together, these changes produce the Long R3 structure investigated in experimental growth-factor research.

The molecular formula listed by Core Peptides is C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉, with a molecular weight of approximately 9,117.5 g/mol.

IGF-1 LR3 and IGF-Binding Proteins

Insulin-like growth factors interact with a group of proteins known as IGF-binding proteins (IGFBPs). These proteins can influence the availability, distribution and interaction of IGF molecules within biological systems.

One of the key research characteristics of IGF-1 LR3 is its reported lower affinity for IGF-binding proteins compared with native IGF-1. Researchers have investigated whether this altered interaction contributes to differences in peptide distribution and receptor availability in experimental models.

This makes IGF-1 LR3 useful in research designed to examine the relationship between growth-factor structure, IGFBP interactions and IGF receptor signalling.

Receptor Grade IGF-1 LR3 and IGF-1 Receptor Research

The IGF-1 receptor (IGF-1R) is a cell-surface receptor involved in signalling processes associated with cellular growth, development, metabolism and other biological functions.

IGF-1-related peptides are therefore widely studied in molecular and cellular biology. Research involving IGF-1 LR3 has examined how structural changes to the IGF molecule can influence receptor-related activity and downstream cellular signalling.

IGF-related signalling can involve several intracellular pathways, including pathways associated with cellular growth and survival. However, responses vary according to the experimental model, cell type and conditions used in each study.

IGF-1 LR3 and Tissue Distribution Research

Experimental studies have investigated the distribution of IGF-1 LR3 compared with endogenous IGF-1. Core Peptides cites research using labelled IGF-1 LR3 in murine models, where the synthetic peptide was observed to clear from serum and distribute into tissues. Increased tracer concentrations were reported in organs including the kidneys, ovaries and adrenal glands.

These findings are relevant to laboratory investigations into how structural changes to IGF molecules can influence tissue distribution and availability.

The researchers proposed that differences in interaction with IGF-binding proteins could contribute to the observed distribution pattern. Such observations should be understood as experimental findings rather than established human pharmacokinetic properties.

Receptor Grade IGF-1 LR3 and Anabolic Research

IGF-1 LR3 has been investigated in experimental models examining anabolic and tissue-related processes. Core Peptides references research involving normal and dexamethasone-treated rats, in which IGF-1 variants were investigated for effects associated with tissue anabolism and protein metabolism.

Reported experimental observations included changes in body weight, visceral organ weight and feed efficiency under specific study conditions. The same research also investigated N^τ-methylhistidine excretion, a marker associated with muscle protein degradation.

These findings provide a basis for further preclinical research into IGF-related anabolic mechanisms. They should not, however, be interpreted as evidence of an approved anabolic therapy or equivalent effects in humans.

IGF-1 LR3 and Metabolic Research

IGF-related signalling is also an important subject in metabolic research. Experimental studies have investigated the relationship between IGF-binding proteins, glucose uptake and intracellular signalling pathways.

Research cited by Core Peptides discusses potential connections between IGF-related signalling and pathways including PI3K and AMPK, which are involved in cellular metabolism and glucose regulation.

Such research can help scientists investigate how growth-factor signalling interacts with metabolic pathways at the cellular level. Findings from mechanistic or animal research should not be presented as evidence of therapeutic efficacy in humans.

Receptor Grade IGF-1 LR3 and Muscle Research

IGF signalling is relevant to research into muscle-cell development, differentiation and protein metabolism. IGF-1 LR3 has consequently been investigated in experimental muscle models.

Core Peptides references research involving female mice examining IGF-1 analogues in relation to myostatin, a protein involved in regulating muscle-cell differentiation and growth. The research explored whether IGF-related signalling could influence mechanisms associated with muscle-cell protection and myostatin activity.

These studies contribute to the broader understanding of relationships between growth factors and muscle biology, but animal findings cannot be assumed to translate directly to humans.

IGF-1 LR3 Research Applications

Receptor Grade IGF-1 LR3 can be of interest to qualified researchers investigating areas such as:

IGF-1 receptor biology and receptor-mediated signalling.
Growth-factor research and cellular communication.
IGF-binding protein interactions.
Cell growth and differentiation.
Muscle-cell biology and myostatin-related mechanisms.
Metabolic signalling and glucose-related cellular research.
Protein metabolism and anabolic mechanisms.
Tissue distribution and peptide behaviour studies.
Structure–activity relationship research.
Comparative studies involving IGF-1 and modified IGF analogues.
In-vitro cell-culture research.
Preclinical growth-factor investigations.

Receptor Grade IGF-1 LR3 vs Native IGF-1

Characteristic	Native IGF-1	Receptor Grade IGF-1 LR3
Amino-acid length	70 amino acids	83 amino acids
N-terminal structure	Native structure	13-amino-acid extension
Residue 3	Glutamic acid	Arginine
IGFBP interaction	Native IGF-binding behaviour	Reportedly reduced interaction with IGFBPs
Research relevance	Endogenous IGF-1 biology	Modified IGF signalling and receptor research

The structural differences between native IGF-1 and IGF-1 LR3 are central to research into how peptide modifications influence binding and signalling behaviour.

Why Choose Receptor Grade IGF-1 LR3 (1mg)?

Receptor Grade IGF-1 LR3 (1mg) offers qualified laboratories a defined research material for controlled investigations into IGF-related biology.

1mg research quantity: Supplied in a defined 1mg format.
>99% listed purity: Designed for research applications requiring a high-purity peptide material.
Lyophilised format: Supplied as a dry peptide powder.
Distinct molecular structure: Features the Long R3 modifications that distinguish it from native IGF-1.
Broad research relevance: Suitable for investigations involving receptor biology, growth-factor signalling and cellular mechanisms.
Research documentation: The product page provides access to a Certificate of Analysis for batch-specific information.

Receptor Grade IGF-1 LR3 Storage and Laboratory Handling

As a lyophilised research peptide, Receptor Grade IGF-1 LR3 should be handled according to the supplier’s current technical documentation and the laboratory’s established procedures.

Keep the material in its original, appropriately labelled container.
Protect the lyophilised material from unnecessary exposure to moisture.
Follow the supplier’s specified storage conditions.
Minimise unnecessary temperature fluctuations.
Use appropriate laboratory handling procedures.
Review the relevant Certificate of Analysis and product documentation before use.

Storage and handling requirements can vary depending on the material, packaging and intended research application. Researchers should therefore follow the applicable supplier documentation and institutional protocols.

Analytical Research with IGF-1 LR3

Laboratories working with synthetic peptide materials may employ analytical methods to evaluate identity, purity and experimental consistency. Depending on the study, researchers may consider techniques such as:

High-performance liquid chromatography (HPLC): For chromatographic purity assessment.
Mass spectrometry: For molecular identity and mass confirmation.
Cell-based assays: For investigating receptor-related cellular responses.
Comparative assays: For comparing IGF-1 LR3 with native IGF-1 or other analogues.
Peptide characterisation: For evaluating molecular properties relevant to the research protocol.

Where experimental accuracy is important, researchers should use the current batch-specific Certificate of Analysis supplied with the product.

Research Evidence for Receptor Grade IGF-1 LR3

Research into IGF-1 LR3 includes laboratory and animal investigations examining tissue distribution, anabolic mechanisms, metabolic signalling and muscle-related biology. Core Peptides cites studies involving murine models and peer-reviewed literature concerning IGF-1 and related growth-factor mechanisms.

The supplier itself notes that the research base examining the anabolic properties of IGF-1 LR3 remains limited and that the peptide is primarily designed for evaluation in cell-culture studies.

Consequently, experimental findings should be interpreted according to the specific model, methodology, species, cell type, exposure conditions and endpoints used. Results from animal or in-vitro studies should not be extrapolated automatically to human use.

Frequently Asked Questions About Receptor Grade IGF-1 LR3 (1mg)

What is Receptor Grade IGF-1 LR3?

Receptor Grade IGF-1 LR3 is a synthetic analogue of insulin-like growth factor-1 containing an extended N-terminal sequence and an arginine substitution at residue 3. It is supplied as a research material for laboratory and analytical investigations.

What does LR3 mean?

LR3 refers to the Long R3 structure of the peptide. “Long” describes the additional N-terminal sequence, while “R3” refers to the arginine residue at position 3.

How many amino acids does IGF-1 LR3 contain?

Native IGF-1 contains 70 amino acids, whereas IGF-1 LR3 contains 83 amino acids because of its additional 13-amino-acid N-terminal extension.

What is the purity of Receptor Grade IGF-1 LR3 (1mg)?

The Core Peptides product page lists the 1mg presentation with a purity of >99%.

What form is Receptor Grade IGF-1 LR3 supplied in?

The 1mg product is supplied as a lyophilised powder.

What is the molecular weight of IGF-1 LR3?

Core Peptides lists the molecular weight as approximately 9,117.5 g/mol and the molecular formula as C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉.

What is IGF-1 LR3 researched for?

Research involving IGF-1 LR3 has examined growth-factor signalling, IGF-binding proteins, tissue distribution, metabolic mechanisms, muscle biology and cellular responses.

Is Receptor Grade IGF-1 LR3 approved for human use?

No. Core Peptides states that its products are sold for research, laboratory or analytical purposes only and are not intended for human consumption.

Has IGF-1 LR3 been studied in animals?

Yes. Experimental research has investigated IGF-1 LR3 in animal models, including studies examining tissue distribution, anabolic mechanisms and muscle-related processes.

Is IGF-1 LR3 the same as natural IGF-1?

No. IGF-1 LR3 is a modified analogue. It contains an additional 13 amino acids at the N-terminus and an arginine substitution at residue 3, producing a distinct molecular structure.

What is the difference between Receptor Grade and Media Grade IGF-1 LR3?

Core Peptides describes Receptor Grade as a higher-purity research material compared with Media Grade. The 1mg Receptor Grade product is listed at >99% purity.

Receptor Grade IGF-1 LR3 (1mg) Research Summary

Receptor Grade IGF-1 LR3 (1mg) is a high-purity, lyophilised synthetic analogue of insulin-like growth factor-1 designed for qualified research and laboratory applications.

Its 83-amino-acid structure, extended N-terminus and Arg3 modification distinguish it from native IGF-1. These characteristics have made the peptide a subject of research into IGF receptor signalling, IGF-binding proteins, tissue distribution, cellular growth, metabolic activity and muscle-related mechanisms.

The 1mg format provides a defined quantity for controlled analytical, laboratory and in-vitro research. Because the available evidence for IGF-1 LR3 includes predominantly preclinical and experimental research, findings should be interpreted within the limitations of each study and should not be presented as evidence of established human therapeutic efficacy.

Research-Use Disclaimer

Receptor Grade IGF-1 LR3 (1mg) is intended solely for qualified research, laboratory, analytical and in-vitro experimental purposes. It is not intended for human or veterinary consumption, self-administration, diagnosis, treatment, cure or prevention of any disease.

References to anabolic activity, muscle biology, cellular growth, metabolism, tissue distribution or other biological effects describe areas of scientific investigation and should not be interpreted as medical claims or established clinical benefits.

Researchers should review the applicable Certificate of Analysis, product documentation, safety information and relevant legislation before working with this material. Handling, storage and disposal should be performed by appropriately trained personnel using suitable laboratory procedures.

For research use only. Human and animal consumption prohibited.

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